Description

2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester, Trichloroacetimidate is a high-purity, advanced glycosyl donor intermediate critical for synthetic carbohydrate chemistry. This compound is engineered to provide exceptional reactivity and stereoselectivity in glycosylation reactions, enabling the efficient construction of complex oligosaccharides and glycoconjugates. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for the synthesis of novel therapeutics, vaccines, and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key glycosyl donor for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, especially those requiring glucuronide conjugation for targeted delivery or detoxification pathways.
• Glycobiology Research: Used in academic and industrial labs to synthesize defined oligosaccharides, glycopeptides, and glycolipids for studying carbohydrate-protein interactions and biological signaling.
• Vaccine Development: Critical for constructing carbohydrate antigens and conjugate vaccines against bacterial pathogens, where specific sugar sequences are vital for immunogenicity.
• Diagnostic Reagent Synthesis: Employed in creating labeled glycans and probes for diagnostic assays and imaging techniques.
• Process Development & Scale-up: Serves as a reliable intermediate for process chemistry teams scaling up glycosylation steps from milligram to kilogram scale under GMP conditions.

Basic Information

Product Name	2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester, Trichloroacetimidate
CAS No.	197895-54-8
Molecular Formula	C15H18Cl3NO10
Molecular Weight	502.66 g/mol
Synonyms	Methyl (2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate) trichloroacetimidate; (2,3,4-Tri-O-acetyl-β-D-glucopyranosyluronic acid methyl ester) trichloroacetimidate; Trichloroacetimidate glucuronate donor; Glucuronic acid methyl ester trichloroacetimidate, peracetylated; Glycosyl Donor CAS 197895-54-8
EINECS	Contact for details

Quality Control

Our 2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester, Trichloroacetimidate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality commitment aligns with the standards required for pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.