Description

(4R,5R)-(-)-2,2-Dimethyl-A,A,A',A'-Tetra(1-Naphthyl)-1,3-Dioxolane-4,5-Dimethanolatotitanium(Iv) Dichloride Acetonitrile Adduct is a highly specialized, chiral titanium-based organometallic complex used as a stereoselective catalyst. This compound is critical for enabling precise asymmetric synthesis, a cornerstone of modern pharmaceutical and advanced materials manufacturing. It is primarily required by R&D chemists and process engineers in the fine chemical, pharmaceutical, and agrochemical industries for the development and production of enantiomerically pure active ingredients.

Application

• Asymmetric Catalysis: As a chiral Lewis acid catalyst for enantioselective Diels-Alder, aldol, and other carbon-carbon bond-forming reactions.
• Pharmaceutical Intermediates: Synthesis of chiral building blocks and active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Polymer Science: Catalyst for the stereoregular polymerization of olefins to produce polymers with specific tacticity.
• Agrochemical Synthesis: Production of chiral herbicides, fungicides, and pesticides where biological activity is stereospecific.
• Academic & Industrial R&D: A key reagent for methodological development in organic synthesis and catalysis research.
• Fine Chemical Production: Manufacture of specialty flavors, fragrances, and other high-value chiral compounds.

Basic Information

Product Name	(4R,5R)-(-)-2,2-Dimethyl-A,A,A',A'-Tetra(1-Naphthyl)-1,3-Dioxolane-4,5-Dimethanolatotitanium(Iv) Dichloride Acetonitrile Adduct
CAS No.	197389-47-2
Molecular Formula	C55H46Cl2N2O4Ti
Molecular Weight	917.77 g/mol
Synonyms	TADDOL-Titanium Dichloride Acetonitrile Adduct; (R,R)-TADDOLatotitanium Dichloride Acetonitrile Complex; Titanium TADDOLate Dichloride Acetonitrile Adduct; (4R,5R)-(-)-TADDOL-TiCl2·CH3CN; (R,R)-TADDOL-TiCl2·NCMe; Titanium(IV) (R,R)-TADDOLate Dichloride Acetonitrile Solvate; Chiral Titanium TADDOL Catalyst
EINECS	Contact for details

Quality Control

Our (4R,5R)-(-)-TADDOL-Titanium Dichloride Acetonitrile Adduct is manufactured under controlled conditions to ensure batch-to-batch consistency and high catalytic activity. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral integrity is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade its catalytic performance.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Titanium (Ti) Content	4.8 - 5.3 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.