Description

Pyridazine, 4-(Trimethylsilyl)- (9Ci) is a specialized organosilicon derivative of the pyridazine heterocycle, serving as a valuable synthetic building block in advanced organic chemistry. This compound is particularly significant for introducing the trimethylsilyl (TMS) group, a versatile protecting and directing moiety, into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the pyridazine core's bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems.
• Ligand Synthesis: Utilized in the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	Pyridazine, 4-(Trimethylsilyl)- (9Ci)
CAS No.	194865-87-7
Molecular Formula	C7H12N2Si
Molecular Weight	152.27 g/mol
Synonyms	4-(Trimethylsilyl)pyridazine; 4-Trimethylsilylpyridazine; 4-Pyridazine, 4-(trimethylsilyl)-; Pyridazine, 4-(trimethylsilyl)-; 4-TMS-Pyridazine; 1,2-Diazine, 4-(trimethylsilyl)-; (4-Pyridazinyl)trimethylsilane
EINECS	Contact for details

Quality Control

Every batch of Pyridazine, 4-(Trimethylsilyl)- is produced and analyzed under strict quality management protocols to ensure consistency and purity for research and development applications. Our standard analytical suite includes identification by spectroscopic methods (NMR, IR) and purity determination by chromatographic techniques (GC, HPLC). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.