Description

(S)-2,2,3,3,11,11-Hexamethyl-9-Oxo-4,10-Dioxa-8-Aza-3-Siladodecane-7-Carboxylic Acid is a high-purity, organosilicon-protected amino acid derivative of significant value in advanced synthetic chemistry. This compound matters as a sophisticated chiral building block, enabling the precise construction of complex molecules with defined stereochemistry. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel active pharmaceutical ingredients (APIs), peptides, and other high-value specialty chemicals where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for protease inhibitors and other targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate protected amino acid units, preventing unwanted side reactions.
• Asymmetric Synthesis: Serves as a precursor or auxiliary in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Protecting Group Chemistry: The siloxane-based protecting groups offer orthogonal deprotection strategies critical for multi-step synthetic sequences.
• Bioconjugation & Linker Chemistry: Potential use in creating cleavable linkers for antibody-drug conjugates (ADCs) or prodrug strategies.
• Material Science Research: Exploration of novel silicon-containing polymers or hybrid organic-inorganic materials with specific functionalities.

Basic Information

Product Name	(S)-2,2,3,3,11,11-Hexamethyl-9-Oxo-4,10-Dioxa-8-Aza-3-Siladodecane-7-Carboxylic Acid
CAS No.	191655-45-5
Molecular Formula	C15H29NO6Si
Molecular Weight	347.48 g/mol
Synonyms	(S)-N-[(tert-Butoxycarbonyl)-O-(tert-butyldimethylsilyl)]-serine; Boc-Ser(TBDMS)-OH; (2S)-2-[[(tert-Butoxy)carbonyl]amino]-3-[[tert-butyl(dimethyl)silyl]oxy]propanoic acid; N-Boc-O-TBDMS-L-serine; Boc-L-Ser(TBDMS)-OH; N-[(tert-Butoxycarbonyl)-O-(tert-butyldimethylsilyl)]-L-serine; L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-[1,1-dimethylethyl)dimethylsilyl]-; (S)-2-((tert-Butoxycarbonyl)amino)-3-((tert-butyldimethylsilyl)oxy)propanoic acid
EINECS	Contact for details

Quality Control

Our production of (S)-2,2,3,3,11,11-Hexamethyl-9-Oxo-4,10-Dioxa-8-Aza-3-Siladodecane-7-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.