Description

(3Ar,5R,6R,6Ar)-5-(((tert-Butyldiphenylsilyl)Oxy)Methyl)-2,2-Dimethyltetrahydrofuro[2,3-D][1,3]Dioxol-6-Ol is a sophisticated chiral building block and protected sugar derivative of significant value in advanced organic synthesis. Its core value lies in its role as a key intermediate for constructing complex nucleoside analogs and other biologically active molecules, offering precise stereochemical control. This compound is essential for research and development teams in the pharmaceutical, agrochemical, and fine chemical industries focused on antiviral, anticancer, and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• Chiral Building Block: Used in asymmetric synthesis to introduce complex carbohydrate-like frameworks into target molecules with high enantiomeric purity.
• Antiviral Pro-drug Development: Serves as a protected intermediate in the development of pro-drugs for improved bioavailability and targeted delivery of active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Employed in the research and production of advanced, stereospecific agrochemicals and plant growth regulators.
• Fine Chemical Production: Utilized in custom synthesis and contract manufacturing for high-value, specialty chemicals requiring specific stereochemistry.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and glycoscience research.

Basic Information

Product Name	(3Ar,5R,6R,6Ar)-5-(((tert-Butyldiphenylsilyl)Oxy)Methyl)-2,2-Dimethyltetrahydrofuro[2,3-D][1,3]Dioxol-6-Ol
CAS No.	190970-10-6
Molecular Formula	C26H34O6Si
Molecular Weight	470.63 g/mol
Synonyms	5-O-(tert-Butyldiphenylsilyl)-1,2-O-isopropylidene-α-D-glucofuranurono-6,3-lactone; 1,2-O-Isopropylidene-5-O-(tert-butyldiphenylsilyl)-α-D-glucofuranurono-6,3-lactone; TBDPS-protected glucofuranurono lactone; (3aR,5R,6R,6aR)-5-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]methyl]-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol; Protected D-glucofuranurono-6,3-lactone derivative; TBDPS-glucofuranuronolactone; CAS 190970-10-6
EINECS	Contact for details

Quality Control

Our production of this high-purity synthetic intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.