Description

3,6-Dihydro-2H-Pyran-4-Yl Trifluoro-Methanesulfonate is a versatile and highly reactive triflate ester derivative of a dihydropyran, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a superior leaving group, enabling efficient carbon-carbon and carbon-heteroatom bond formation under mild conditions, which is essential for constructing complex molecular architectures. This compound is particularly valuable for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who are developing active ingredients, novel materials, and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the construction of complex heterocyclic scaffolds and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the preparation of novel herbicides, fungicides, and plant growth regulators.
• Cross-Coupling Reactions: An effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi).
• Material Science: Building block for monomers and polymers with specific optical or electronic properties.
• Medicinal Chemistry: Enables rapid analoging and structure-activity relationship (SAR) studies through efficient functionalization.
• Catalyst & Ligand Development: Intermediate in the synthesis of sophisticated organometallic catalysts and chiral ligands.

Basic Information

Product Name	3,6-Dihydro-2H-Pyran-4-Yl Trifluoro-Methanesulfonate
CAS No.	188975-30-6
Molecular Formula	C7H7F3O4S
Molecular Weight	244.19 g/mol
Synonyms	3,6-Dihydro-2H-pyran-4-yl triflate; 4-(Trifluoromethanesulfonyloxy)-3,6-dihydro-2H-pyran; 3,6-Dihydro-2H-pyran-4-yl trifluoromethanesulfonate; 2H-Pyran, 3,6-dihydro-, 4-trifluoromethanesulfonate; 4-Triflyloxy-3,6-dihydro-2H-pyran; DHP-OTf; 3,4-Dihydro-2H-pyran-4-yl triflate (tautomer)
EINECS	Contact for details

Quality Control

Our 3,6-Dihydro-2H-Pyran-4-Yl Trifluoro-Methanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We adhere to cGMP principles where applicable, and all products are supported by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.