Description

(1R,2S)-2-(Tributylstannyl)Cyclopropanemethanol is a high-value, chiral organotin building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the stereoselective construction of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing cyclopropane-containing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of cyclopropane-based drug candidates, including protease inhibitors and other biologically active molecules.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the cyclopropane moiety imparts specific biological activity and stability.
• Cross-Coupling Reactions: Serves as a stannane reagent in Stille cross-coupling reactions to form new carbon-carbon bonds with high stereochemical fidelity.
• Material Science Research: Employed in the synthesis of specialized monomers and polymers with unique structural properties derived from the strained cyclopropane ring.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric transformations to introduce chiral cyclopropane units into target molecules.
• Chemical Biology Probes: Acts as a building block for creating labeled compounds and molecular probes used in mechanistic studies and target identification.

Basic Information

Item	Details
Product Name	(1R,2S)-2-(Tributylstannyl)Cyclopropanemethanol
CAS No.	188620-19-1
Molecular Formula	C15H32OSn
Molecular Weight	347.12 g/mol
Synonyms	(1R,2S)-2-(Tributylstannyl)cyclopropylmethanol; [(1R,2S)-2-(Hydroxymethyl)cyclopropyl]tributylstannane; (-)-trans-2-(Tributylstannyl)cyclopropanemethanol; Tributyl[(1R,2S)-2-(hydroxymethyl)cyclopropyl]stannane; (1R,2S)-2-(Tributylstannyl)cyclopropanecarbinol; (1R,2S)-rel-2-(Tributylstannyl)cyclopropanemethanol; Chiral tributyltin cyclopropanemethanol
EINECS	Contact for details

Quality Control

Our (1R,2S)-2-(Tributylstannyl)Cyclopropanemethanol is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to ensure optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Tin (Sn) Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.