Description

2-Amino-4,5-Bis(4-Methylphenyl)-3-Furonitrile is a specialized furonitrile derivative, a key heterocyclic building block in advanced organic synthesis. Its molecular structure, featuring amino and nitrile functional groups on a furan core flanked by tolyl substituents, makes it a valuable precursor for constructing complex pharmacophores and functional materials. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active compounds and advanced polymers.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where its heterocyclic core can contribute to unique modes of action and improved efficacy.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the synthesis of specialty polymers, dyes, and organic electronic materials due to its conjugated system and reactive sites.
• Chemical Synthesis Reagent: Employed in academic and industrial R&D for constructing complex heterocyclic frameworks via cyclization and cross-coupling reactions.
• Ligand and Catalyst Development: Utilized to create novel chelating ligands for metal catalysts used in asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	2-Amino-4,5-Bis(4-Methylphenyl)-3-Furonitrile
CAS No.	187793-06-2
Molecular Formula	C20H16N2O
Molecular Weight	300.36 g/mol
Synonyms	2-Amino-4,5-di-p-tolyl-3-furonitrile; 4,5-Bis(4-methylphenyl)-2-amino-3-furonitrile; 3-Furonitrile, 2-amino-4,5-bis(4-methylphenyl)-; 2-Amino-4,5-bis(4-methylphenyl)furan-3-carbonitrile; 2-Amino-4,5-di(4-methylphenyl)furan-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Amino-4,5-Bis(4-Methylphenyl)-3-Furonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and process development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.