Description

(5S)-5,7-Bis-[(tert-Butyldimethylsilyl)Oxy]-4,4-Dimethylheptan-3-One CAS NO 187527-25-9 is a high-purity, chiral synthetic intermediate featuring dual tert-butyldimethylsilyl (TBDMS) protecting groups. This compound is critical for its role in advanced organic synthesis, particularly in the stereoselective construction of complex molecules where precise control over hydroxyl group reactivity is required. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates, especially in steroid and terpenoid-related pathways.
• Asymmetric Synthesis: Used in reactions requiring the selective protection and deprotection of diol functionalities to control regiochemistry and stereochemistry.
• Academic & Process Chemistry Research: Serves as a valuable reagent for methodological development in organic chemistry laboratories and for scaling up synthetic routes.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require high enantiomeric purity.
• Reference Standard: Can be utilized as an analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(5S)-5,7-Bis-[(tert-Butyldimethylsilyl)Oxy]-4,4-Dimethylheptan-3-One
CAS No.	187527-25-9
Molecular Formula	C21H46O3Si2
Molecular Weight	402.77 g/mol
Synonyms	(5S)-5,7-Bis[(tert-butyldimethylsilyl)oxy]-4,4-dimethyl-3-heptanone; 3-Heptanone, 5,7-bis[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4-dimethyl-, (5S)-; (5S)-5,7-Bis-O-(tert-butyldimethylsilyl)-4,4-dimethylheptan-3-one; (5S)-5,7-Bis(tert-butyldimethylsiloxy)-4,4-dimethyl-3-heptanone; TBDMS-protected chiral diol ketone; (5S)-4,4-Dimethyl-5,7-bis[(2-methyl-2-propanyl)dimethylsilyl]oxy]heptan-3-one
EINECS	Contact for details

Quality Control

Our production of (5S)-5,7-Bis-[(tert-Butyldimethylsilyl)Oxy]-4,4-Dimethylheptan-3-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.