Description

Cyclopropanecarboxaldehyde, 2-(Phenylmethyl)-, cis- (9Ci) CAS NO 187335-53-1 is a specialized chiral aldehyde building block featuring a cyclopropane ring and a benzyl substituent. This compound matters for its unique three-dimensional structure, which is highly valuable in the synthesis of complex, biologically active molecules where stereochemistry is critical. Pharmaceutical research and development organizations need it as a key intermediate for creating novel active pharmaceutical ingredients (APIs), particularly in areas like antiviral, anticancer, and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the multi-step synthesis of potential drug candidates, especially where the cis-configuration of the cyclopropane ring is required for biological activity.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the cyclopropane moiety can contribute to unique modes of action and improved stability.
• Asymmetric Synthesis: Employed as a starting material or reagent in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules for medicinal chemistry.
• Fragrance & Flavor Chemistry: Acts as a precursor for synthesizing novel aroma chemicals with unique olfactory properties derived from its constrained cyclic structure.
• Material Science: Investigated as a monomer or cross-linking agent for creating polymers with specific thermal or mechanical properties due to the strain energy of the cyclopropane ring.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development in organic synthesis and exploring new chemical spaces.

Basic Information

Product Name	Cyclopropanecarboxaldehyde, 2-(Phenylmethyl)-, cis- (9Ci)
CAS No.	187335-53-1
Molecular Formula	C11H12O
Molecular Weight	160.21 g/mol
Synonyms	cis-2-Benzylcyclopropanecarboxaldehyde; (1S,2R)-2-Benzylcyclopropane-1-carbaldehyde; 2-(Phenylmethyl)cyclopropanecarboxaldehyde, cis-; Benzylcyclopropanecarboxaldehyde; (cis)-2-Benzyl-1-cyclopropanecarboxaldehyde
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxaldehyde, 2-(Phenylmethyl)-, cis- is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and degradation. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral GC/HPLC)	≥ 98.0% cis-isomer
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.