Description

5-Chloro-2-(2,2,2-trifluoroethoxy)aniline is a high-value fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and trifluoroethoxy substituents, makes it an essential intermediate for creating compounds with enhanced biological activity and specific physicochemical properties. This product is primarily required by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the trifluoroethoxy group can contribute to improved metabolic stability and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, leveraging its electronic properties.
• Dye & Pigment Intermediate: Employed in the production of specialized, high-performance dyes and pigments requiring halogenated aniline structures.
• Cross-Coupling Reactions: Acts as a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to construct complex nitrogen-containing heterocycles.
• Chemical Research & Development: Utilized in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	5-Chloro-2-(2,2,2-trifluoroethoxy)aniline
CAS No.	186387-91-7
Molecular Formula	C8H7ClF3NO
Molecular Weight	225.59 g/mol
Synonyms	2-Amino-4-chloro-1-(2,2,2-trifluoroethoxy)benzene; 4-Chloro-2-(2,2,2-trifluoroethoxy)aniline; 5-Chloro-2-(2,2,2-trifluoroethoxy)benzenamine; 1-(2,2,2-Trifluoroethoxy)-4-chloro-2-aminobenzene; 186387-91-7; 5-Chloro-2-(2,2,2-trifluoroethoxy)phenylamine
EINECS	Contact for details

Quality Control

Our production of 5-Chloro-2-(2,2,2-trifluoroethoxy)aniline adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and GC for residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support custom synthesis and can tailor purity grades to meet specific project requirements, from standard technical grade to high-purity research grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.