Description

(R,E)-n-Benzylidene-2-Methylpropane-2-Sulfinamide is a high-purity chiral sulfinamide building block, a key intermediate in asymmetric synthesis. Its primary value lies in its role as a versatile chiral auxiliary and ligand for the stereoselective construction of nitrogen-containing compounds, particularly amines. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high enantiomeric purity in their synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical chiral auxiliary in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), especially for amine-based drugs.
• Asymmetric Synthesis: Used as a chiral controller in nucleophilic addition reactions to imines, enabling the production of chiral amines with high diastereoselectivity.
• Agrochemical Development: Employed in the research and production of chiral pesticides and herbicides where specific stereochemistry is required for optimal activity.
• Catalyst and Ligand Preparation: Serves as a precursor for chiral ligands used in transition metal catalysis for various asymmetric transformations.
• Academic and R&D: A valuable reagent for methodological development in organic and medicinal chemistry research within university and corporate laboratories.
• Fine Chemical Production: Utilized in the custom synthesis of complex, high-value specialty chemicals for advanced material science and electronics.

Basic Information

Product Name	(R,E)-n-Benzylidene-2-Methylpropane-2-Sulfinamide
CAS No.	186249-76-3
Molecular Formula	C₁₁H₁₅NOS
Molecular Weight	209.31 g/mol
Synonyms	(R,E)-N-Benzylidene-tert-butanesulfinamide; (R,E)-N-(Phenylmethylene)-2-methylpropane-2-sulfinamide; (R)-tert-Butanesulfinamide benzylidene derivative; (R,E)-N-(Benzylidene)-2-methyl-2-propanesulfinamide; (R,E)-N-(Phenylmethylidene)-2-methylpropane-2-sulfinamide; (R,E)-tert-Butylsulfinyl imine (benzaldehyde derived); (R,E)-N-(Benzylidene)-tert-butylsulfinamide
EINECS	Contact for details

Quality Control

Our (R,E)-n-Benzylidene-2-Methylpropane-2-Sulfinamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive asymmetric synthesis. Certificates of Analysis (COA) with full characterization data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.