Description

Boc-Thionoala-1-(6-Nitro)Benzotriazolide is a specialized peptide coupling reagent and activated ester derivative used in advanced organic synthesis. This compound is critical for the efficient and selective formation of peptide bonds, particularly in the synthesis of complex peptides and modified amino acid derivatives. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for the production of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Peptide Synthesis: As an activated ester for the coupling of Boc-protected thioalanine in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediate: Key building block in the research and development of peptide-based therapeutics and prodrugs.
• Bioconjugation: Used for labeling and modifying peptides, proteins, and other biomolecules with specific functional groups.
• Chemical Biology Research: Tool compound for studying enzyme mechanisms and protein-protein interactions involving cysteine or thiol analogs.
• Agrochemical Development: Intermediate in the synthesis of novel peptide-mimetic pesticides and plant growth regulators.
• Material Science: Precursor for creating functionalized polymers and surfaces with peptide motifs.

Basic Information

Product Name	Boc-Thionoala-1-(6-Nitro)Benzotriazolide
CAS No.	184951-86-8
Molecular Formula	C16H19N5O5S
Molecular Weight	393.42 g/mol
Synonyms	1-[(6-Nitro-1H-benzotriazol-1-yl)oxy]-2,5-pyrrolidinedione, 3-[(1,1-Dimethylethoxy)carbonyl]thio-L-alanine ester; tert-Butyloxycarbonyl-thioalanine-6-nitrobenzotriazolyl ester; Boc-S-Ala-ONb; Boc-Thioalanine 6-Nitrobenzotriazolide; N-(tert-Butoxycarbonyl)-3-thioalanine 6-nitrobenzotriazol-1-yl ester; Activated ester of Boc-thioalanine; Boc-L-Thionoala-ONb
EINECS	Contact for details

Quality Control

Our Boc-Thionoala-1-(6-Nitro)Benzotriazolide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.