Description

Sodium (2-Sulfonatoethyl)Methanethiosulfonate is a specialized organosulfur compound with a unique bifunctional structure, serving as a key reagent in advanced chemical synthesis and modification. Its primary value lies in its ability to act as a versatile, water-soluble crosslinking agent and a source of reactive thiol groups under controlled conditions. This makes it particularly valuable for researchers and manufacturers in the pharmaceutical and bioconjugation sectors who require precise, site-specific modifications of proteins, peptides, and other biomolecules. The compound's sulfonate group enhances its solubility in aqueous systems, facilitating reactions in biological buffers.

Application

• Bioconjugation and Protein Modification: Used as a heterobifunctional crosslinker for introducing disulfide bonds or for the site-specific labeling of antibodies, enzymes, and other proteins.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) that require thioether or disulfide linkages.
• Polymer Chemistry: Employed in the synthesis and functionalization of hydrogels and smart polymers, where its dual reactivity can be used to control crosslink density and introduce responsive elements.
• Surface Functionalization: Applied to modify the surface of nanoparticles, gold surfaces, or chromatographic media with thiol-reactive groups for biosensor development or affinity purification.
• Research Reagent: A valuable tool in biochemical and chemical research for studying thiol-disulfide exchange reactions and redox processes.
• Peptide Synthesis: Used in solid-phase peptide synthesis (SPPS) for the introduction of protected or activatable thiol functionalities into peptide chains.

Basic Information

Product Name	Sodium (2-Sulfonatoethyl)Methanethiosulfonate
CAS No.	184644-83-5
Molecular Formula	C3H6NaO5S3
Molecular Weight	248.24 g/mol
Synonyms	Sodium 2-(Methanethiosulfonato)ethanesulfonate; 2-(Methanethiosulfonyl)ethanesulfonic Acid Sodium Salt; (2-Sulfonatoethyl) Methanethiosulfonate Sodium Salt; MTSES; Sodium MTSES; MTSEA-Sulfonate; Sodium Salt of (2-Sulfonatoethyl)methanethiosulfonate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request. We adhere to strict in-process controls to guarantee batch-to-batch consistency and reliability for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which may affect stability and performance. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Solubility	Freely soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.