Description

1-(2-(5-(Dimethylamino)-1-Napthalenesulfonamido)Ethyl)-1,4,7,10-Tetraazacyclododecane, Tetrahydrochloride, Dihydrate is a high-purity, functionalized macrocyclic chelator derivative, specifically designed for advanced research and development applications. This compound is valued for its ability to form stable complexes with metal ions, making it a critical intermediate in the synthesis of sophisticated diagnostic and therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, radiopharmaceutical developers, and advanced materials scientists working on next-generation imaging and targeted drug delivery systems.

Application

• Radiopharmaceutical Precursor: A key intermediate in the synthesis of novel radiolabeled compounds for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging agents.
• Contrast Agent Development: Serves as a bifunctional chelator for attaching diagnostic metal ions (e.g., Gadolinium, Gallium) to targeting vectors like antibodies or peptides in Magnetic Resonance Imaging (MRI) contrast media research.
• Therapeutic Radiopharmaceuticals: Used in the development of targeted alpha or beta therapy (TAT/TRT) agents for oncology, where precise delivery of radioactive isotopes to cancer cells is required.
• Chemical Biology Probes: Enables the creation of fluorescent or metal-tagged probes for studying biological processes, cell signaling, and receptor mapping in vitro and in vivo.
• Catalysis Research: Acts as a ligand scaffold for designing novel transition metal catalysts used in asymmetric synthesis and green chemistry applications.
• Material Science: Employed in the functionalization of surfaces and nanoparticles for creating smart materials with specific metal-binding or sensing properties.

Basic Information

Product Name	1-(2-(5-(Dimethylamino)-1-Napthalenesulfonamido)Ethyl)-1,4,7,10-Tetraazacyclododecane, Tetrahydrochloride, Dihydrate
CAS No.	184537-03-9
Molecular Formula	C26H48Cl4N6O6S
Molecular Weight	690.57 g/mol
Synonyms	DOTA-DANSYL; DOTA-Dansylamide; Dansyl-DOTA; 1-(2-((5-(Dimethylamino)naphthalene-1-sulfonamido)ethyl)-1,4,7,10-tetraazacyclododecane tetrahydrochloride dihydrate; 1,4,7,10-Tetraazacyclododecane-1-(2-(5-(dimethylamino)-1-naphthalenesulfonamido)ethyl) tetrahydrochloride dihydrate; DOTA-Dns; DOTA-Dansyl chelator
EINECS	Contact for details

Quality Control

Our production of this advanced chemical intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under cGMP guidelines where required for pre-clinical and clinical-stage projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	4.5% - 6.5% (Theoretical for dihydrate ~5.2%)
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.