Description

3,5-Bis(Trifluoromethyl)Benzyl Methanesulphonate is a specialized organofluorine building block and alkylating agent of significant importance in advanced chemical synthesis. Its core value lies in the introduction of the highly electron-withdrawing bis(trifluoromethyl)benzyl group, which can dramatically alter the physical and electronic properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the trifluoromethyl groups improve compound stability and membrane permeability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Catalyst & Ligand Development: Employed in the design and synthesis of novel organometallic catalysts and chiral ligands for asymmetric synthesis.
• Fluorinated Liquid Crystal Synthesis: A critical intermediate for creating fluorinated mesogens used in high-performance display technologies.
• R&D and Custom Synthesis: A valuable reagent for medicinal chemistry and process chemistry research in both academic and industrial laboratories.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzyl Methanesulphonate
CAS No.	183551-51-1
Molecular Formula	C11H8F6O3S
Molecular Weight	334.24 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzyl methanesulfonate; Methanesulfonic acid [3,5-bis(trifluoromethyl)phenyl]methyl ester; [3,5-Bis(trifluoromethyl)phenyl]methyl methanesulfonate; α-(Methanesulfonyloxy)-3,5-bis(trifluoromethyl)toluene; 3,5-Bis(trifluoromethyl)benzyl mesylate; (3,5-Bis(trifluoromethyl)phenyl)methyl methanesulfonate; 3,5-Bis(trifluoromethyl)benzyl methanesulfonate; Mesylate of 3,5-bis(trifluoromethyl)benzyl alcohol
EINECS	Contact for details

Quality Control

Our production of 3,5-Bis(Trifluoromethyl)Benzyl Methanesulphonate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support cGMP manufacturing standards for pharmaceutical customers and can tailor specifications to meet your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.