Description

2H-Pyran-2-One, 3-(Difluoroacetyl)Tetrahydro-, (+)- (9Ci) is a specialized chiral lactone derivative, distinguished by its difluoroacetyl functional group. This compound is a high-value synthetic intermediate prized for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require enantiomerically pure building blocks for asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of advanced, enantiopure pesticides and herbicides, leveraging its fluorine-containing moiety for enhanced biological activity and metabolic stability.
• Asymmetric Catalysis Research: Serves as a sophisticated substrate or ligand precursor in academic and industrial research focused on developing new catalytic methodologies.
• Flavor & Fragrance Chemistry: Potential intermediate for the synthesis of complex lactone-based aroma chemicals, where the specific stereochemistry influences the olfactory profile.
• Material Science Precursor: Can be utilized in the synthesis of specialized monomers for polymers with tailored properties, benefiting from its rigid, oxygenated heterocyclic structure.

Basic Information

Product Name	2H-Pyran-2-One, 3-(Difluoroacetyl)Tetrahydro-, (+)- (9Ci)
CAS No.	183279-72-3
Molecular Formula	C7H8F2O3
Molecular Weight	178.14 g/mol
Synonyms	(+)-3-(Difluoroacetyl)tetrahydro-2H-pyran-2-one; (3R)-3-(2,2-Difluoroacetyl)oxan-2-one; Tetrahydro-3-(difluoroacetyl)-2H-pyran-2-one, (+)-; (R)-3-(Difluoroacetyl)dihydro-2(3H)-furanone (tautomeric form); 183279-72-3; (R)-3-(2,2-Difluoroacetyl)tetrahydro-2H-pyran-2-one
EINECS	Contact for details

Quality Control

Our 2H-Pyran-2-One, 3-(Difluoroacetyl)Tetrahydro-, (+)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light) and may be incompatible with strong alkali/organic solvent. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.