Description

3-Bromo-5-Trimethylsilanyl-Isoxazole is a high-value organosilicon building block and halogenated heterocycle. This compound is critical for advanced organic synthesis, particularly in the development of novel pharmaceuticals and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those containing functionalized isoxazole rings.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, leveraging its reactive bromine and silyl-protected site.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers and silicon-containing advanced materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form new carbon-carbon bonds.
• Protecting Group Strategy: The trimethylsilyl (TMS) group can be used as a protective moiety for the isoxazole nitrogen or oxygen in multi-step synthetic sequences.
• Ligand Synthesis: Utilized in the preparation of novel nitrogen-oxygen (N,O) chelating ligands for catalysis and coordination chemistry.

Basic Information

Product Name	3-Bromo-5-Trimethylsilanyl-Isoxazole
CAS No.	181947-25-1
Molecular Formula	C7H12BrNOSi
Molecular Weight	234.17 g/mol
Synonyms	3-Bromo-5-(trimethylsilyl)isoxazole; 5-(Trimethylsilyl)-3-bromoisoxazole; 3-Bromo-5-trimethylsilylisoxazole; Isoxazole, 3-bromo-5-(trimethylsilyl)-; 181947-25-1; 3-Bromo-5-(TMS)isoxazole; 3-Br-5-TMS-isoxazole
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Trimethylsilanyl-Isoxazole is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.