Description

4-Fluorophenylzinc Bromide is a versatile organozinc reagent, specifically a fluorinated arylzinc halide, widely used in modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation, particularly in cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where the introduction of a fluorinated phenyl group is a critical synthetic step. Its reactivity profile offers a reliable and selective alternative to other organometallic reagents for functionalizing complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing the 4-fluorophenyl moiety into active pharmaceutical ingredients (APIs) and drug candidates via Negishi, Kumada, or other transition-metal catalyzed cross-couplings.
• Agrochemical Development: Used in the synthesis of herbicides, fungicides, and insecticides where the fluorophenyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized fluorinated ligands used in homogeneous catalysis and material science.
• Advanced Material Research: Employed in the creation of fluorinated organic semiconductors, liquid crystals, and polymers for electronic and optical applications.
• Fine Chemical and Specialty Chemical Production: Facilitates the manufacture of complex fluorinated aromatics used in flavors, fragrances, and dyes.
• Academic and R&D Laboratories: A valuable tool for methodological development in organometallic chemistry and new reaction discovery.

Basic Information

Product Name	4-Fluorophenylzinc Bromide
CAS No.	181705-93-1
Molecular Formula	C6H4FZnBr
Molecular Weight	240.39 g/mol
Synonyms	(4-Fluorophenyl)zinc bromide; Zinc, bromo(4-fluorophenyl)-; 4-Fluorophenylzinc bromide solution; p-Fluorophenylzinc bromide; Bromo(4-fluorophenyl)zinc; (p-Fluorophenyl)zinc bromide
EINECS	Contact for details

Quality Control

Our 4-Fluorophenylzinc Bromide is manufactured under strict quality-controlled conditions to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Quality is verified through analytical techniques including titration (for zinc assay), NMR, and GC/HPLC analysis of representative samples. A Certificate of Analysis (COA) detailing concentration, solvent, and impurity profiles is provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) to prevent decomposition. For solutions, store at recommended temperatures (typically 2-8°C for extended shelf life) as specified on the label. Keep away from heat, sparks, and open flame. Use in a well-ventilated area or fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution (typically in THF or ether)
Concentration	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95%
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.