Description

2-Chloro-4-Fluorophenetole is a versatile halogenated aromatic ether intermediate of significant importance in advanced organic synthesis. Its unique molecular structure, featuring both chloro and fluoro substituents on the phenetole backbone, makes it a valuable building block for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for molecules requiring specific halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro pattern can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a starting material for synthesizing specialized organic compounds used in electronic displays and optoelectronic devices.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce functionalized phenetole units into more complex structures.
• Dye & Pigment Intermediate: Utilized in the development of specialized dyes and pigments where halogen atoms influence color fastness and spectral properties.

Basic Information

Product Name	2-Chloro-4-Fluorophenetole
CAS No.	181305-71-5
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-Chloro-2-Ethoxy-5-Fluorobenzene; 2-Chloro-4-Fluoro-1-Ethoxybenzene; 2-Chloro-4-fluorophenetol; 2-Chloro-4-fluoroanisole (common misnomer, refers to methoxy analog); 5-Fluoro-2-chlorophenetole; Benzene, 1-chloro-2-ethoxy-5-fluoro-; Phenetole, 2-chloro-4-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Fluorophenetole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by GC, HPLC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2°C to 8°C for long-term stability, or at controlled room temperature (15-25°C) for short-term use.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Density	~1.25 g/cm³ (at 20°C)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.