Description

3,6-Dihydro-2H-Thiopyran-4-Yl Trifluoromethanesulfonate, 97% is a high-purity, advanced pharmaceutical intermediate and versatile triflate ester building block. This compound is valued for its reactivity as a leaving group, enabling efficient cross-coupling and functionalization reactions in complex organic synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing sulfur heterocycles.
• Cross-Coupling Reactions: Serves as an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to introduce the dihydrothiopyran moiety.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the creation of functionalized monomers and ligands for catalysts or advanced polymers.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological pathways and target engagement.
• Process Chemistry: Utilized in route scouting and optimization for scalable manufacturing of fine chemicals.

Basic Information

Product Name	3,6-Dihydro-2H-Thiopyran-4-Yl Trifluoromethanesulfonate, 97%
CAS No.	181180-42-7
Molecular Formula	C7H9F3O3S2
Molecular Weight	262.27 g/mol
Synonyms	3,6-Dihydro-2H-thiopyran-4-yl triflate; 4-(Trifluoromethanesulfonyloxy)-3,6-dihydro-2H-thiopyran; 3,4-Dihydro-2H-thiopyran-4-yl trifluoromethanesulfonate; 4-Triflyloxy-3,6-dihydro-2H-thiopyran; 3,6-Dihydro-2H-thiopyran-4-ol triflate; 4-Hydroxy-3,6-dihydro-2H-thiopyran trifluoromethanesulfonate ester; THP-4-OTf; Dihydrothiopyran-4-yl triflate
EINECS	Contact for details

Quality Control

Our 3,6-Dihydro-2H-Thiopyran-4-Yl Trifluoromethanesulfonate, 97% is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting cGMP and ISO 9001 compliant workflows for our global customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.