Description

1-Acetylazetidin-3-One is a high-value, versatile azetidine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and the development of novel pharmaceutical agents, particularly due to its reactive ketone functionality within a constrained four-membered ring. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of β-lactam antibiotics, protease inhibitors, and other bioactive molecules targeting various disease pathways.
• Medicinal Chemistry Scaffold: Used in drug discovery programs to introduce the azetidine ring, a privileged structure known for improving metabolic stability and potency.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides and fungicides with unique modes of action.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring functionalized azetidine cores.

Basic Information

Product Name	1-Acetylazetidin-3-One
CAS No.	179894-05-4
Molecular Formula	C5H7NO2
Molecular Weight	113.11 g/mol
Synonyms	3-Oxoazetidine-1-acetate; 1-Acetyl-3-azetidinone; 3-Acetamidoazetidine; N-Acetyl-3-azetidinone; Azetidin-3-one, 1-acetyl-; 1-Acetylazetidin-3-one; 3-Oxo-1-azetidineacetic acid; 1-Acetyl-3-oxoazetidine
EINECS	Contact for details

Quality Control

Our 1-Acetylazetidin-3-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is supplied with every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.