Description

4-(3,5-Difluorophenyl)Tetrahydro-2H-Pyran-4-Carbonitrile is a high-value fluorinated heterocyclic building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals due to its unique structural motif. It is primarily utilized by R&D chemists and process development scientists in the life sciences and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the stability of the fluorinated phenyl group.
• Material Science Research: Used in the development of specialty polymers and liquid crystals where fluorinated units enhance thermal and chemical stability.
• Organic Synthesis Reagent: Serves as a versatile scaffold for constructing complex molecules via reactions at the nitrile and pyran ring functionalities.
• Chemical Biology Probe Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	4-(3,5-Difluorophenyl)Tetrahydro-2H-Pyran-4-Carbonitrile
CAS No.	179421-07-9
Molecular Formula	C12H11F2NO
Molecular Weight	223.22 g/mol
Synonyms	4-(3,5-Difluorophenyl)tetrahydro-2H-pyran-4-carbonitrile; 4-(3,5-Difluorophenyl)oxane-4-carbonitrile; 4-Cyano-4-(3,5-difluorophenyl)tetrahydropyran; 4-(3,5-Difluorophenyl)-4-cyanotetrahydropyran; 179421-07-9; 4-(3,5-Difluorophenyl)-4-cyanotetrahydro-2H-pyran; 4-(3,5-Difluorophenyl)-4-pyrancarbonitrile
EINECS	Contact for details

Quality Control

Our 4-(3,5-Difluorophenyl)Tetrahydro-2H-Pyran-4-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.