Description

(E)-N-(4-((tert-Butyldimethylsilyl)oxy)benzylidene)-4-fluoroaniline is a high-purity, advanced pharmaceutical intermediate featuring a protected phenolic group and a fluorinated aromatic system. This compound is critical for enabling complex synthetic routes in medicinal chemistry, particularly for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate specific fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of fluorinated drug candidates, including kinase inhibitors and receptor antagonists.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated aromatic components in electronic and display materials.
• Organic Synthesis: Employed in cross-coupling reactions and as a substrate for further functionalization due to its reactive imine and protected phenol groups.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) ether group allows for selective deprotection in multi-step syntheses.
• Fluorine Chemistry Research: A valuable compound for studying structure-activity relationships (SAR) in fluorinated aromatic systems.

Basic Information

Product Name	(E)-N-(4-((tert-Butyldimethylsilyl)oxy)benzylidene)-4-fluoroaniline
CAS No.	179411-51-9
Molecular Formula	C19H24FNOSi
Molecular Weight	329.49 g/mol
Synonyms	4-(((4-Fluorophenyl)imino)methyl)phenol TBDMS ether; N-(4-(tert-Butyldimethylsilyloxy)benzylidene)-4-fluoroaniline; (E)-4-((tert-Butyldimethylsilyl)oxy)-N-(4-fluorophenyl)benzaldimine; 4-Fluoro-N-[(4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl)methylene]benzenamine; 179411-51-9; TBDMS-protected 4-fluoroaniline Schiff base
EINECS	Contact for details

Quality Control

Our (E)-N-(4-((tert-Butyldimethylsilyl)oxy)benzylidene)-4-fluoroaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.