Description

Mpeg-Dspe CAS NO 178744-28-0 is a high-purity, functionalized phospholipid derivative widely used as a critical excipient in advanced pharmaceutical formulations. This compound is essential for creating stable, targeted drug delivery systems, particularly in nanomedicine. It is primarily utilized by research institutions and pharmaceutical manufacturers developing liposomal and micellar therapeutics for oncology, gene therapy, and diagnostic imaging applications.

Application

• Liposome Formulation: A key component in the synthesis of PEGylated (stealth) liposomes for prolonged circulation and reduced immunogenicity.
• Targeted Drug Delivery: Used to conjugate targeting ligands (e.g., antibodies, peptides) to lipid nanoparticles for site-specific therapeutic action.
• mRNA & Gene Delivery Systems: An important building block in lipid nanoparticles (LNPs) for the encapsulation and delivery of nucleic acids.
• Diagnostic Agent Carrier: Facilitates the stable encapsulation of contrast agents for magnetic resonance imaging (MRI) or other imaging modalities.
• Micelle Stabilization: Acts as a stabilizer and functional component in polymeric micelles used for solubilizing poorly water-soluble drugs.
• Surface Modification: Employed to modify the surface properties of biomaterials and implants to improve biocompatibility and reduce protein adsorption.

Basic Information

Product Name	Mpeg-Dspe
CAS No.	178744-28-0
Molecular Formula	C13H26NO10P (Base structure varies with PEG chain length 'n')
Molecular Weight	Variable (dependent on PEG chain length). Contact for details.
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)]; DSPE-PEG; DSPE-mPEG; PEG-DSPE; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]; mPEG-DSPE; Poly(ethylene glycol) derivatized distearoylphosphatidylethanolamine; Phospholipid-PEG conjugate
EINECS	Contact for details.

Quality Control

Our Mpeg-Dspe is manufactured under strict quality management systems. Each batch is characterized and tested to ensure high purity, consistent PEG chain length distribution, and low residual solvent levels. Certificates of Analysis (COA) providing detailed specifications for identity, assay, and impurities are available upon request. Production can adhere to cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC / 1H NMR)	≥95.0%
PEG Average Molecular Weight	As ordered (e.g., 2000, 5000 Da)
Dispersity (Đ)	≤1.05
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤1.0%
Phase Transition Temperature	Reported

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.