Description

4-Bromobenzofuran-2-Carboxylic Acid is a high-purity brominated heterocyclic building block of significant importance in advanced organic synthesis. This compound matters as a versatile intermediate, enabling the construction of complex molecular architectures for pharmaceutical and material science research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as medicinal chemistry and the synthesis of functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to introduce the bromobenzofuran scaffold, which can modulate pharmacokinetic properties.
• Agrochemical Research: Serves as a precursor in the synthesis of new generation herbicides and fungicides, leveraging its heterocyclic core for bioactivity.
• Material Science: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-rich furan ring and halogen substituent.
• Chemical Biology: Utilized as a probe or labeling agent in biochemical assays and for the synthesis of enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.

Basic Information

Product Name	4-Bromobenzofuran-2-Carboxylic Acid
CAS No.	177735-22-7
Molecular Formula	C9H5BrO3
Molecular Weight	241.04 g/mol
Synonyms	2-Bromobenzofuran-5-carboxylic Acid; 4-Bromo-1-benzofuran-2-carboxylic Acid; 4-Bromobenzofurane-2-carboxylic Acid; 2-Carboxy-4-bromobenzofuran; 4-Bromo-2-carboxybenzofuran; 177735-22-7 (CAS); 4-Bromobenzofuran-2-carboxylate (Anion form)
EINECS	Contact for details

Quality Control

Our 4-Bromobenzofuran-2-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.