Description

trans-4-(Boc-Amino)Cyclohexyl Methanesulfonate is a high-purity, protected amino acid derivative used as a critical building block in organic synthesis. This compound is essential for the controlled introduction of the trans-4-aminocyclohexyl moiety into complex molecular architectures. It is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology industries for the development of novel active pharmaceutical ingredients (APIs) and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of small molecule drug candidates, particularly those targeting G-protein-coupled receptors (GPCRs).
• Peptide Chemistry: Used to incorporate a rigid, trans-configured cyclohexyl spacer into peptide backbones to enhance metabolic stability and conformational control.
• PROTAC & Molecular Glue Development: Serves as a versatile linker component in the construction of proteolysis-targeting chimeras (PROTACs) and other bifunctional molecules.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and activity-based probes for target identification and validation studies.
• Agrochemical Research: Acts as an intermediate in the development of advanced crop protection agents with improved properties.
• Material Science: A potential monomer or cross-linking agent for creating specialized polymers with amino-functionalized cyclic structures.

Basic Information

Product Name	trans-4-(Boc-Amino)Cyclohexyl Methanesulfonate
CAS No.	177545-89-0
Molecular Formula	C₁₃H₂₅NO₆S
Molecular Weight	323.41 g/mol
Synonyms	trans-4-[(tert-Butoxycarbonyl)amino]cyclohexyl methanesulfonate; (1r,4r)-4-[(tert-Butoxycarbonyl)amino]cyclohexyl methanesulfonate; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexanol methanesulfonate (trans); trans-4-(N-Boc-amino)cyclohexyl mesylate; Boc-trans-4-aminocyclohexanol mesylate; trans-4-(tert-Butoxycarbonylamino)cyclohexyl mesylate; (trans)-4-(Boc-amino)cyclohexyl methanesulfonate
EINECS	Contact for details

Quality Control

Our trans-4-(Boc-Amino)Cyclohexyl Methanesulfonate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.