Description

(S)-Benzyl 2-(tert-Butoxycarbonylamino)-2-(4-(Trifluoromethylsulfonyloxy)Phenyl)Acetate is a high-purity, non-natural amino acid derivative featuring a chiral center and a reactive triflate ester group. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, enabling precise stereochemical control in advanced pharmaceutical development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of novel therapeutics, including protease inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for constructing active pharmaceutical ingredients (APIs) with specific stereochemistry.
• Peptidomimetic Synthesis: Used in the design and synthesis of peptide analogs and mimetics for drug discovery programs.
• Protease Inhibitor Development: Serves as a core structural component in the research of inhibitors for various protease enzymes.
• Chemical Biology Research: Employed as a tool compound or building block in studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce chiral amino acid motifs.
• Process Chemistry & Scale-Up: Provides a defined chiral starting material for optimizing synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	(S)-Benzyl 2-(tert-Butoxycarbonylamino)-2-(4-(Trifluoromethylsulfonyloxy)Phenyl)Acetate
CAS No.	176505-40-1
Molecular Formula	C21H22F3NO7S
Molecular Weight	489.46 g/mol
Synonyms	(S)-Benzyl 2-((tert-Butoxycarbonyl)amino)-2-(4-((trifluoromethyl)sulfonyloxy)phenyl)acetate; (S)-Benzyl N-Boc-4-triflyloxy-phenylglycinate; N-Boc-O-triflyl-L-phenylglycine benzyl ester; (S)-Benzyl 2-(Boc-amino)-2-[4-(trifluoromethanesulfonyloxy)phenyl]acetate; BOC-Phe(4-OTf)-OBzl; BOC-L-4-Triflyloxy-phenylglycine benzyl ester; (S)-α-((tert-Butoxycarbonyl)amino)-4-(trifluoromethylsulfonyloxy)benzeneacetic acid benzyl ester
EINECS	Contact for details

Quality Control

Every batch of (S)-Benzyl 2-(tert-Butoxycarbonylamino)-2-(4-(Trifluoromethylsulfonyloxy)Phenyl)Acetate is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity compliant with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.