Description

n-(4-Hydroxymethylbenzyl) Cyclam CAS NO 176252-20-3 is a functionalized macrocyclic tetraamine ligand, specifically a cyclam derivative bearing a hydroxymethylbenzyl substituent. This structural modification is critical for enhancing metal ion chelation properties and facilitating covalent attachment to surfaces or other molecules. It is primarily sought by researchers and manufacturers in the fields of molecular imaging, radiopharmaceuticals, catalysis, and advanced material science for developing targeted diagnostic and therapeutic agents.

Application

• Radiopharmaceutical Precursor: Acts as a bifunctional chelator for labeling antibodies, peptides, or small molecules with diagnostic (e.g., 64Cu, 68Ga) or therapeutic (e.g., 177Lu) radioisotopes for PET imaging and targeted radiotherapy.
• Contrast Agent Development: Serves as a building block for synthesizing high-relaxivity MRI contrast agents by chelating gadolinium (Gd3+) or other lanthanide ions.
• Catalysis Research: Used to create immobilized or homogeneous metal complexes (with Cu, Ni, Zn) for catalytic applications, including oxidation and hydrolysis reactions.
• Sensor and Diagnostic Platform Fabrication: The pendant hydroxymethyl group allows for conjugation to polymers, nanoparticles, or solid supports to create selective sensors for metal ions or biological analytes.
• Bioconjugation and Protein Labeling: Facilitates the site-specific attachment of metal complexes to biomolecules for studies in bioinorganic chemistry and cellular imaging.
• Material Functionalization: Employed to modify the surface of mesoporous silica, magnetic nanoparticles, or other nanomaterials to impart metal-binding capabilities.

Basic Information

Product Name	n-(4-Hydroxymethylbenzyl) Cyclam
CAS No.	176252-20-3
Molecular Formula	C19H32N4O
Molecular Weight	332.49 g/mol
Synonyms	1,4,8,11-Tetraazacyclotetradecane, 1-(4-(hydroxymethyl)benzyl)-; 1-(4-Hydroxybenzyl)-1,4,8,11-tetraazacyclotetradecane; 4-(Hydroxymethyl)benzyl-cyclam; H2BzCyclam; p-Hydroxymethylbenzyl-cyclam; Bifunctional Cyclam Derivative; 1,4,8,11-Tetraazacyclotetradecane, 1-[(4-(hydroxymethyl)phenyl)methyl]-
EINECS	Contact for details

Quality Control

Our n-(4-Hydroxymethylbenzyl) Cyclam is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and elemental analysis, to ensure it meets the high standards required for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.