Description

Maleimidocaproic Acid Hydrazide-HCl is a heterobifunctional crosslinking reagent featuring a maleimide group and a hydrazide moiety, activated with a hydrochloride salt. This compound is critically important for the site-specific conjugation of biomolecules, enabling the creation of stable, well-defined conjugates for advanced research and diagnostics. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay formulation.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key chemical bridge for attaching cytotoxic payloads to monoclonal antibodies via the hydrazide group, enabling targeted cancer therapies.
• Protein and Peptide Labeling: Used for the covalent attachment of fluorescent dyes, enzymes, or other probes to proteins through the maleimide-thiol chemistry, essential for imaging and detection.
• Surface Immobilization: Facilitates the oriented coupling of antibodies or other proteins to activated surfaces (e.g., biosensor chips, microplates) for diagnostic and research applications.
• Polymer Modification: Enables the functionalization of polymers or nanoparticles with biological ligands, creating advanced drug delivery systems and biomaterials.
• Diagnostic Reagent Synthesis: A critical component in the production of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassay reagents.
• Biomolecule Crosslinking: Used to create covalent bonds between different biomolecules (e.g., protein-protein, protein-oligonucleotide) for structural studies or to generate novel bioactive complexes.

Basic Information

Item	Details
Product Name	Maleimidocaproic Acid Hydrazide-HCl
CAS No.	175290-73-0
Molecular Formula	C10H16ClN3O3
Molecular Weight	261.71 g/mol
Synonyms	6-Maleimidocaproic Acid Hydrazide Hydrochloride; Maleimidocaproyl Hydrazide Hydrochloride; EMCH Hydrochloride; 6-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide Hydrochloride; N-(ε-Maleimidocaproyl)hydrazine Hydrochloride; 1-(6-Hydrazinyl-6-oxohexyl)-1H-pyrrole-2,5-dione Hydrochloride; MC Hydrazide-HCl; Maleimidocaproic Hydrazide HCl
EINECS	Contact for details

Quality Control

Our Maleimidocaproic Acid Hydrazide-HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for water content, to ensure it meets the stringent requirements for bioconjugation research. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Under these conditions, the product is typically stable for at least 24 months. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.