Description

3-Bromo-6-(trifluoromethyl)pyridazine is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling the development of advanced materials and active ingredients. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for use in medicinal chemistry, crop protection research, and the synthesis of specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Serves as a crucial building block for creating new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Used in the synthesis of advanced organic electronic materials, such as ligands for OLEDs and components for organic semiconductors.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig couplings to form complex biaryl structures.
• Fluorine Chemistry: The trifluoromethyl group provides metabolic stability and lipophilicity, making it valuable for optimizing the pharmacokinetic properties of lead compounds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Item	Detail
Product Name	3-Bromo-6-(trifluoromethyl)pyridazine
CAS No.	174607-37-5
Molecular Formula	C5H2BrF3N2
Molecular Weight	226.98 g/mol
Synonyms	3-Bromo-6-(trifluoromethyl)pyridazine; 6-Bromo-3-(trifluoromethyl)pyridazine; 3-Bromo-6-trifluoromethylpyridazine; 174607-37-5; Pyridazine, 3-bromo-6-(trifluoromethyl)-; 6-Trifluoromethyl-3-bromopyridazine; 3-Bromo-6-(trifluoromethyl)-1,2-diazine
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-6-(trifluoromethyl)pyridazine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed impurity profiling available. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.