Description

(S)-4-Ethyl-4-Hydroxy-6-Iodo-8-Methoxy-1,4-Dihydro-Pyrano[3,4-C]Pyridin-3-One is a high-purity, chiral organic compound featuring a complex fused pyranopyridine core structure. This molecule is of significant commercial interest as a key synthetic intermediate or building block in advanced pharmaceutical research and development. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities with targeted biological activity.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Asymmetric Synthesis: Utilized as a substrate or intermediate in catalytic asymmetric reactions due to its defined (S)-stereochemistry.
• Reference Standard: Acts as a high-purity analytical standard for method development, validation, and quality control in API manufacturing.
• Chemical Biology Probes: Potential use in the development of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(S)-4-Ethyl-4-Hydroxy-6-Iodo-8-Methoxy-1,4-Dihydro-Pyrano[3,4-C]Pyridin-3-One
CAS No.	174092-79-6
Molecular Formula	C12H14INO4
Molecular Weight	363.15 g/mol
Synonyms	(S)-4-Ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydropyrano[3,4-c]pyridin-3-one; 1,4-Dihydropyrano[3,4-c]pyridin-3-one, 4-ethyl-4-hydroxy-6-iodo-8-methoxy-, (4S)-; (4S)-4-Ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydropyrano[3,4-c]pyridin-3-one; 174092-79-6; (S)-enantiomer of the pyranopyridinone derivative. Contact for additional trade names or abbreviations.
EINECS	Contact for details

Quality Control

Our (S)-4-Ethyl-4-Hydroxy-6-Iodo-8-Methoxy-1,4-Dihydro-Pyrano[3,4-C]Pyridin-3-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.