Description

(S)-4-Ethyl-4-Hydroxy-8-Methoxy-6-Trimethylsilanyl-1,4-Dihydro-Pyrano[3,4-C]Pyridin-3-One is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry, essential for the synthesis of complex active pharmaceutical ingredients (APIs). Its value lies in its role as a key chiral building block, enabling the production of enantiomerically pure compounds critical for modern drug development. This product is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on developing novel therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of proprietary APIs and investigational new drugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new biological entities.
• Process Chemistry: Serves as a key starting material or intermediate in scaling up synthetic routes from laboratory to pilot and commercial production.
• Asymmetric Synthesis: Leveraged for constructing complex molecular architectures with high stereoselectivity in organic synthesis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and commercial drug substances.

Basic Information

Product Name	(S)-4-Ethyl-4-Hydroxy-8-Methoxy-6-Trimethylsilanyl-1,4-Dihydro-Pyrano[3,4-C]Pyridin-3-One
CAS No.	174092-78-5
Molecular Formula	C16H25NO4Si
Molecular Weight	323.46 g/mol
Synonyms	(S)-4-Ethyl-4-hydroxy-8-methoxy-6-(trimethylsilyl)-1,4-dihydropyrano[3,4-c]pyridin-3-one; 1,4-Dihydropyrano[3,4-c]pyridin-3-one, 4-ethyl-4-hydroxy-8-methoxy-6-(trimethylsilyl)-, (4S)-; (4S)-4-Ethyl-4-hydroxy-8-methoxy-6-(trimethylsilyl)-1,4-dihydropyrano[3,4-c]pyridin-3-one; 174092-78-5; S-4-Ethyl-4-Hydroxy-8-Methoxy-6-Trimethylsilanyl-1,4-Dihydro-Pyrano[3,4-C]Pyridin-3-One; TMS-protected pyranopyridinone intermediate
EINECS	Contact for details

Quality Control

Our (S)-4-Ethyl-4-Hydroxy-8-Methoxy-6-Trimethylsilanyl-1,4-Dihydro-Pyrano[3,4-C]Pyridin-3-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistent performance as a synthetic intermediate. Certificates of Analysis (COA) detailing purity (typically by HPLC), chiral purity, identity (IR, NMR), and residual solvent levels are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.