Description

1-Trimethylsilyloxy-4-Pentyne is a versatile organosilicon reagent featuring both a silyl-protected hydroxyl group and a terminal alkyne functionality. This bifunctional nature makes it a valuable building block in organic synthesis, particularly for constructing complex molecular architectures. It is primarily used by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring alkyne coupling reactions (e.g., Sonogashira, Click chemistry).
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides where the alkyne moiety is incorporated into the final active compound.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers, silicones, and functionalized surfaces with tailored properties.
• Ligand & Catalyst Development: Employed in the preparation of sophisticated ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Protecting Group Strategy: The trimethylsilyloxy (OTMS) group acts as a protecting group for alcohols, which can be selectively deprotected under mild conditions.
• Chemical Research: A fundamental reagent in academic and industrial R&D for exploring new synthetic methodologies and constructing complex organic molecules.

Basic Information

Product Name	1-Trimethylsilyloxy-4-Pentyne
CAS No.	174064-03-0
Molecular Formula	C8H16OSi
Molecular Weight	156.30 g/mol
Synonyms	4-Pentyn-1-ol, 1-(trimethylsilyl)-; 1-(Trimethylsilyl)-4-pentyn-1-ol; 4-(Trimethylsilyloxy)-1-butyne; 1-Trimethylsiloxy-4-pentyne; TMS-Protected 4-Pentyn-1-ol; (4-Pentyn-1-yloxy)trimethylsilane; 4-Pentynyloxytrimethylsilane; O-Trimethylsilyl-4-pentyn-1-ol
EINECS	Contact for details

Quality Control

Our 1-Trimethylsilyloxy-4-Pentyne is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed when not in use and away from heat, sparks, and open flames. Store away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.