Description

7-Hydroxy-2-(Trifluoromethyl)-4H-Chromen-4-One is a high-purity fluorinated chromenone derivative, a key synthetic intermediate prized for its unique trifluoromethyl group which imparts enhanced metabolic stability and lipophilicity to target molecules. Its primary commercial value lies in enabling the efficient synthesis of advanced pharmaceutical compounds and agrochemicals, where the introduction of fluorine is a critical design strategy. This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-inflammatory research, leveraging the bioisosteric properties of the trifluoromethyl group.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the fluorinated moiety enhances compound activity, stability, and environmental profile.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor for electron-transport or emissive layer materials in display and lighting technologies due to its chromone core structure.
• Fluorescent Probe & Dye Chemistry: Acts as a scaffold for developing sensitive fluorescent tags and molecular probes used in biochemical assays and diagnostic imaging.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting fundamental research in medicinal chemistry, organic synthesis, and fluorine chemistry.
• Advanced Material Monomer: Potential use as a specialty monomer for synthesizing high-performance polymers with specific optical or electronic properties.

Basic Information

Product Name	7-Hydroxy-2-(Trifluoromethyl)-4H-Chromen-4-One
CAS No.	172739-50-3
Molecular Formula	C10H5F3O3
Molecular Weight	230.14 g/mol
Synonyms	7-Hydroxy-2-(trifluoromethyl)chromen-4-one; 2-(Trifluoromethyl)-7-hydroxy-4H-chromen-4-one; 7-Hydroxy-2-trifluoromethylchromone; 4H-1-Benzopyran-4-one, 7-hydroxy-2-(trifluoromethyl)-; 7-Hydroxy-2-trifluoromethyl-4-chromone; 7-Hydroxy-2-(trifluoromethyl)-4-chromone; 2-Trifluoromethyl-7-hydroxy-4H-chromen-4-one
EINECS	Contact for details

Quality Control

Our 7-Hydroxy-2-(Trifluoromethyl)-4H-Chromen-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure compliance with exacting standards for advanced synthetic intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.