Description

3-((Benzyloxy)Methyl)Cyclobutanone is a versatile and synthetically valuable organic building block characterized by its cyclobutanone core functionalized with a benzyloxymethyl side chain. This compound matters as a key chiral intermediate and precursor in advanced pharmaceutical synthesis and fine chemical manufacturing, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and catalyst development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing strained ring systems for enhanced biological activity.
• Medicinal Chemistry Building Block: Used in high-throughput screening and the development of novel drug candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Employed in the research and production of advanced herbicides, fungicides, and plant growth regulators that require specific stereochemistry.
• Chiral Auxiliary and Ligand Precursor: Utilized for the preparation of chiral catalysts and ligands used in asymmetric synthesis to control stereoselectivity.
• Fine Chemical Production: Acts as a starting material for synthesizing specialty chemicals, flavors, fragrances, and advanced materials.
• Academic and Industrial Research: A valuable reagent for methodological development in organic synthesis, including ring-expansion and cross-coupling reactions.

Basic Information

Product Name	3-((Benzyloxy)Methyl)Cyclobutanone
CAS No.	172324-67-3
Molecular Formula	C12H14O2
Molecular Weight	190.24 g/mol
Synonyms	3-(Benzyloxymethyl)cyclobutanone; Cyclobutanone, 3-[(phenylmethoxy)methyl]-; 3-(Phenylmethoxymethyl)cyclobutanone; (3-Oxocyclobutyl)methyl benzyl ether; Benzyl (3-oxocyclobutyl)methyl ether
EINECS	Contact for details

Quality Control

Our 3-((Benzyloxy)Methyl)Cyclobutanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound may be sensitive to prolonged exposure to air and moisture; consider storage under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.