Description

2H-Pyran-2-One, 6-Ethynyltetrahydro-4-Hydroxy-, (4R-Cis)- (9Ci) is a high-purity, stereochemically defined lactone derivative of significant interest in advanced organic synthesis. This compound matters as a versatile chiral building block, offering a unique scaffold for constructing complex molecular architectures with precise stereocontrol. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the creation of advanced, biologically active molecules for crop protection and pest management solutions.
• Organic Synthesis Building Block: Serves as a versatile precursor for constructing complex heterocyclic compounds and natural product analogs due to its reactive ethynyl and lactone functionalities.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new catalytic asymmetric transformations.
• Flavor & Fragrance Chemistry: Potential intermediate for the synthesis of specialized lactone-based aroma chemicals.
• Material Science Research: Investigated as a monomer or cross-linking agent for the development of novel polymeric materials with specific properties.

Basic Information

Product Name	2H-Pyran-2-One, 6-Ethynyltetrahydro-4-Hydroxy-, (4R-Cis)- (9Ci)
CAS No.	171895-59-3
Molecular Formula	C7H8O3
Molecular Weight	140.14 g/mol
Synonyms	(4R,6R)-6-Ethynyl-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one; (4R-cis)-6-Ethynyltetrahydro-4-hydroxy-2H-pyran-2-one; 6-Ethynyl-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one; Tetrahydro-6-ethynyl-4-hydroxy-2H-pyran-2-one; 171895-59-3; (4R,6R)-6-Ethynyl-4-hydroxy-tetrahydro-2H-pyran-2-one
EINECS	Contact for details

Quality Control

Our 2H-Pyran-2-One, 6-Ethynyltetrahydro-4-Hydroxy-, (4R-Cis)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.