Description

Cyclopentylzinc Bromide is a highly reactive organozinc reagent, specifically a cyclopentyl nucleophile, widely used in modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation, particularly in the synthesis of complex, sterically hindered molecules that are difficult to access with other reagents. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise and reliable cross-coupling reactions.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing the cyclopentyl moiety in active pharmaceutical ingredients (APIs) and drug candidates.
• Negishi Cross-Coupling Reactions: Used in palladium-catalyzed couplings with aryl, heteroaryl, or vinyl halides to construct complex molecular architectures.
• Agrochemical Development: Employed in the synthesis of novel pesticides and herbicides that incorporate cyclopentyl rings for enhanced biological activity.
• Ligand and Catalyst Preparation: Serves as a building block for creating specialized phosphine ligands and organometallic catalysts.
• Material Science Research: Used in the development of organic semiconductors and advanced polymers with tailored properties.
• Stereoselective Synthesis: Facilitates the creation of chiral centers in natural product synthesis and fine chemical manufacturing.

Basic Information

Item	Details
Product Name	Cyclopentylzinc Bromide
CAS No.	171860-68-7
Molecular Formula	C5H9BrZn
Molecular Weight	202.42 g/mol
Synonyms	Bromocyclopentylzinc; Cyclopentylzinc bromide solution; Zinc, bromocyclopentyl-; Bromo(cyclopentyl)zinc; Cyclopentylzinc bromide, 0.5 M in THF
EINECS	Contact for details

Quality Control

Our Cyclopentylzinc Bromide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as concentration, purity, and impurity profile. We adhere to cGMP guidelines where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C (refrigerated) or as specified on the label. Due to its highly volatile, hygroscopic, and pyrophoric nature, it must be handled exclusively in a glove box or using standard Schlenk-line techniques to prevent exposure to moisture and air.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (Typical)	0.5 M in Tetrahydrofuran (THF)
Assay (Titration)	≥ 95%
Identification (NMR/IR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm
Metals Impurity Profile (ICP-MS)	Report available

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.