Description

2-Adamantylzinc Bromide is a highly valuable organozinc reagent used for the efficient introduction of the rigid, lipophilic adamantyl group into organic molecules. This compound matters for its role as a key building block in advanced organic synthesis, particularly in cross-coupling reactions like Negishi coupling. Pharmaceutical, agrochemical, and materials science researchers need it for developing novel active ingredients and functional materials with enhanced stability and specific properties. Its utility is central to medicinal chemistry for creating drug candidates with improved metabolic profiles.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially those targeting central nervous system (CNS) disorders, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides where the adamantyl moiety can confer stability and unique biological activity.
• Materials Science: Employed in the synthesis of advanced organic materials, including metal-organic frameworks (MOFs), liquid crystals, and polymers with specific thermal or mechanical properties.
• Negishi Cross-Coupling Reactions: Serves as a robust organozinc reagent for coupling with various aryl, heteroaryl, and vinyl halides to form C-C bonds under mild conditions.
• Catalyst & Ligand Development: Used to create novel organometallic catalysts and ligands for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes for studying biological systems and protein-ligand interactions.

Basic Information

Product Name	2-Adamantylzinc Bromide
CAS No.	171860-65-4
Molecular Formula	C10H15BrZn
Molecular Weight	280.53 g/mol
Synonyms	2-Adamantylzinc Bromide; Zinc, bromo(2-adamantyl)-; Bromo(2-adamantyl)zinc; 2-Adamantylzinc bromide solution; Adamantan-2-ylzinc bromide; (2-Adamantyl)zinc bromide; 2-Adamantyl zinc bromide; Bromo(2-tricyclo[3.3.1.13,7]decyl)zinc
EINECS	Contact for details

Quality Control

Our 2-Adamantylzinc Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and solution concentration (typically provided as a solution in tetrahydrofuran or other suitable solvents). A comprehensive Certificate of Analysis (COA) detailing assay (by titration or NMR), residual solvent content, and other critical parameters is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and hygroscopic (moisture-sensitive), the product must be stored under a dry, inert gas (argon or nitrogen) atmosphere. For long-term stability, store at 2-8°C. Keep the container tightly sealed in a cool, dry, well-ventilated place. Once opened, use immediately or take appropriate precautions to exclude air and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (Zn basis)	≥ 95%
Solvent	Tetrahydrofuran (THF)
Water Content (KF)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.