Description

3,4-Dihydro-1H-2-Benzopyran-1S-Acetic Acid is a chiral, non-racemic organic compound featuring a benzopyran core structure. This specific stereoisomer is a valuable pharmaceutical intermediate and building block in advanced organic synthesis, prized for its defined stereochemistry which is critical for biological activity. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs) and other complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Serves as a crucial building block for constructing complex, stereochemically defined molecules in medicinal chemistry and process development.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new synthetic pathways and developing proprietary chemical entities.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Ligand and Catalyst Precursor: Potential use in the development of chiral ligands or organocatalysts for enantioselective transformations.

Basic Information

Product Name	3,4-Dihydro-1H-2-Benzopyran-1S-Acetic Acid
CAS No.	170856-84-5
Molecular Formula	C11H12O3
Molecular Weight	192.21 g/mol
Synonyms	(1S)-3,4-Dihydro-1H-2-benzopyran-1-acetic acid; (S)-3,4-Dihydro-1H-isochromene-1-acetic acid; (S)-1,2,3,4-Tetrahydro-1-isoquinolineacetic acid (related structure); (S)-Chroman-1-acetic acid; (1S)-1,2,3,4-Tetrahydro-1-isoquinolineacetic acid; (S)-1-Carboxymethyl-1,2,3,4-tetrahydroisoquinoline; (S)-Tic acid derivative; (S)-1,2,3,4-Tetrahydroisoquinoline-1-acetic acid
EINECS	Contact for details

Quality Control

Our 3,4-Dihydro-1H-2-Benzopyran-1S-Acetic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet the highest standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, chiral purity (enantiomeric excess), and impurity profile. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.