Description

1-Tosyl-3-Pyrrolidinol CAS NO 170456-83-4 is a high-purity, versatile pyrrolidine derivative featuring a tosyl protecting group, making it a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in enabling the efficient construction of complex molecular architectures, particularly for pharmaceuticals and agrochemicals, where precise stereochemistry is paramount. This compound is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to develop new active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing central nervous system (CNS) drugs, kinase inhibitors, and antiviral agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the pyrrolidine scaffold contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioactive Molecule Construction: Integral for designing and synthesizing peptide analogs and other bioactive compounds that mimic natural substrates.
• Academic and R&D Laboratories: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and novel compound library generation.
• Fine Chemical Production: Acts as a specialized intermediate in the custom synthesis of complex, high-value chemicals for various industrial applications.

Basic Information

Item	Details
Product Name	1-Tosyl-3-Pyrrolidinol
CAS No.	170456-83-4
Molecular Formula	C11H15NO3S
Molecular Weight	241.31 g/mol
Synonyms	3-Hydroxy-1-(p-toluenesulfonyl)pyrrolidine; 1-(4-Methylphenyl)sulfonyl-3-pyrrolidinol; 3-Pyrrolidinol, 1-[(4-methylphenyl)sulfonyl]-; N-Tosyl-3-hydroxypyrrolidine; 1-Tosyl-3-hydroxyazolidine; 1-(Tosyl)-3-pyrrolidinol; 3-Hydroxy-N-tosylpyrrolidine
EINECS	Contact for details

Quality Control

Our 1-Tosyl-3-Pyrrolidinol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent quality for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.