Description

(3S)-3-[2-(Mesyloxy)Ethoxy]-4-(Trityloxy)Butyl Methanesulfonate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in nucleoside and nucleotide chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of antiviral and anticancer therapeutics, where precise molecular architecture is essential for biological activity.

Application

• Key Intermediate in Nucleoside Analogue Synthesis: Serves as a crucial building block for the production of modified nucleosides used in antiviral and anticancer drugs.
• Pharmaceutical Research & Development (R&D): Employed in medicinal chemistry for the structure-activity relationship (SAR) study and optimization of novel therapeutic candidates.
• Process Chemistry & Scale-up: Used in the development and optimization of scalable synthetic routes for Good Manufacturing Practice (GMP) production of APIs.
• Prodrug Development: Its protected and activated structure makes it valuable for designing prodrugs to enhance the bioavailability and targeting of parent drug molecules.

Basic Information

Product Name	(3S)-3-[2-(Mesyloxy)Ethoxy]-4-(Trityloxy)Butyl Methanesulfonate
CAS No.	170277-77-7
Molecular Formula	C29H36O8S2
Molecular Weight	576.71 g/mol
Synonyms	(3S)-3-[2-(Methanesulfonyloxy)ethoxy]-4-(triphenylmethoxy)butyl methanesulfonate; 1-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-2-[(methylsulfonyl)oxy]ethane; (3S)-3-(2-Mesyloxyethoxy)-4-trityloxybutyl-1-mesylate; 1,2-O-Isopropylidene-3-O-mesyl-4-C-mesyloxymethyl-D-erythritol (protected intermediate); D-erythritol derivative, bis-mesylate; Trityl-protected bis-mesylate intermediate
EINECS	Contact for details

Quality Control

Every batch of (3S)-3-[2-(Mesyloxy)Ethoxy]-4-(Trityloxy)Butyl Methanesulfonate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), chiral purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.