Description

Cyclohexene, 4-(Difluoromethylene)-5-Fluoro-, (R)- (9Ci) is a high-value, chiral fluorinated organic intermediate with a unique difluoromethylene motif. This compound is critical for introducing fluorine atoms and specific stereochemistry into complex molecular architectures, enhancing properties like metabolic stability and bioavailability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of chiral, fluorinated active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS drug discovery.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the fluorine atoms improve lipophilicity and biological activity.
• Advanced Material Precursor: Serves as a specialty monomer or intermediate in the development of fluorinated polymers and functional materials with unique surface properties.
• Asymmetric Catalysis & Ligand Development: Employed as a substrate or a chiral template in the development of novel catalytic systems and ligands for stereoselective synthesis.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research focused on organofluorine chemistry and the study of difluoromethylene group behavior.

Basic Information

Product Name	Cyclohexene, 4-(Difluoromethylene)-5-Fluoro-, (R)- (9Ci)
CAS No.	169899-24-5
Molecular Formula	C7H7F3
Molecular Weight	148.13 g/mol
Synonyms	(R)-4-(Difluoromethylene)-5-fluorocyclohexene; (R)-5-Fluoro-4-(difluoromethylene)cyclohex-1-ene; 4-(Difluoromethylene)-5-fluoro-(R)-cyclohexene; 1-Cyclohexene, 4-(difluoromethylene)-5-fluoro-, (R)-; (R)-5-Fluoro-4-(difluoromethylidene)cyclohex-1-ene; 169899-24-5; (R)-configuration isomer
EINECS	Contact for details

Quality Control

We supply this chiral fluorinated intermediate in high-purity grades suitable for demanding research and scale-up applications. Our products undergo rigorous quality testing to ensure batch-to-batch consistency, with critical parameters including chiral purity (enantiomeric excess), chemical purity, and identity verified. Certificates of Analysis (COA) detailing specifications and test results (e.g., by Chiral HPLC, GC, NMR) are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term stability, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.