Description

Abetimus is a synthetic immunomodulatory oligonucleotide designed to bind to anti-dsDNA antibodies. This compound is of significant interest in the research and development of targeted therapies for autoimmune conditions. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in immunology and drug discovery.

Application

• Immunological Research: A key tool for studying B-cell tolerance and the modulation of antibody production in autoimmune models.
• Drug Discovery: Serves as a reference standard and active pharmaceutical ingredient (API) in the development of novel treatments for systemic lupus erythematosus (SLE).
• Mechanistic Studies: Used to investigate the specific binding interactions and downstream effects on immune complex formation and clearance.
• Biopharmaceutical Development: Employed in formulation and stability studies for potential parenteral therapeutics.

Basic Information

Product Name	Abetimus
CAS No.	167362-48-3
Molecular Formula	C204H243N78O122P19
Molecular Weight	Approx. 6333.2 g/mol
Synonyms	LJP 394; Abetimus Sodium; Edratide (Note: Edratide is a related peptide, sometimes confused); B-cell toleragen; Anti-dsDNA oligonucleotide; 1,3-Propanediylphosphothioate-linked oligonucleotide; Oligonucleotide toleragen
EINECS	Contact for details

Quality Control

Our Abetimus is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term stability, consider storage at -20°C under desiccant.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (UV Spectrophotometry)	90.0% - 110.0% of labeled amount
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.