Description

2,2'-Methylenebis[(4S)-4-Isopropyl-2-Oxazoline] is a high-value, chiral bis-oxazoline ligand, a key building block in asymmetric synthesis. Its importance lies in its ability to form highly selective metal complexes, enabling the production of enantiomerically pure compounds critical for advanced pharmaceuticals and fine chemicals. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric catalysis, particularly for enantioselective cyclopropanation, Diels-Alder, and aldol reactions.
• Key intermediate in the synthesis of complex pharmaceutical active ingredients (APIs) requiring high enantiomeric purity.
• Building block for the development of novel organocatalysts and polymeric chiral auxiliaries.
• Use in academic and industrial research for method development in asymmetric synthesis.
• Component in the manufacture of advanced materials with specific chiral properties.
• Catalyst modifier for producing fine chemicals and agrochemical intermediates.

Basic Information

Product Name	2,2'-Methylenebis[(4S)-4-Isopropyl-2-Oxazoline]
CAS No.	164976-63-0
Molecular Formula	C15H26N2O2
Molecular Weight	266.38 g/mol
Synonyms	(4S,4'S)-2,2'-Methylenebis(4-isopropyl-4,5-dihydrooxazole); (S,S)-2,2'-Methylenebis(4-isopropyl-2-oxazoline); (S,S)-Methylene-bis(4-iPr-oxazoline); (S,S)-MIBO; (S,S)-2,2'-Methylenebis(4-isopropyl-4,5-dihydrooxazole); Chiral Bis(oxazoline) Ligand; (S,S)-4,4'-Isopropyl-2,2'-bisoxazoline
EINECS	Contact for details

Quality Control

Our 2,2'-Methylenebis[(4S)-4-Isopropyl-2-Oxazoline] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and NMR for structural confirmation, to ensure it meets the high-purity standards required for sensitive catalytic applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.