Description

2-(tert-Butyldimethylsilyl)Oxyl Alcohol Trifluoromethanesulfonate is a specialized organosilicon reagent featuring a triflate leaving group, making it a highly reactive intermediate for advanced organic synthesis. This compound is critical for introducing the tert-butyldimethylsilyl (TBDMS) protecting group under mild conditions, enabling precise control in complex molecular construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of active pharmaceutical ingredients (APIs), fine chemicals, and novel polymers.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the selective protection of hydroxyl groups in multi-step API synthesis, particularly for sensitive or complex drug molecules.
• Nucleoside & Carbohydrate Chemistry: Used in the preparation of protected nucleosides, nucleotides, and sugar derivatives for antiviral and anticancer drug development.
• Polymer & Material Science: Serves as a functionalization agent or initiator in the synthesis of specialty silicones and advanced polymeric materials with tailored properties.
• Agrochemical Manufacturing: Employed in the production of advanced herbicides, fungicides, and plant growth regulators requiring selective protection-deprotection strategies.
• Process Chemistry & Scale-up: Valued for its reactivity and selectivity in pilot plant and commercial-scale manufacturing of high-value fine chemicals.
• Research & Development: An essential tool in academic and industrial labs for methodological development and the synthesis of novel chemical entities.

Basic Information

Product Name	2-(tert-Butyldimethylsilyl)Oxyl Alcohol Trifluoromethanesulfonate
CAS No.	164162-36-1
Molecular Formula	C9H19F3O4SSi
Molecular Weight	308.39 g/mol
Synonyms	2-(Tert-Butyldimethylsilyloxy)ethyl Triflate; 2-[(tert-Butyldimethylsilyl)oxy]ethyl Trifluoromethanesulfonate; 2-(TBDMS-Oxy)ethyl Triflate; 2-Hydroxyethyl TBDMS Ether Triflate; TBDMS-Protected Ethanol Triflate; 2-[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethyl Trifluoromethanesulfonate; 2-(tert-Butyldimethylsiloxy)ethyl Trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Every batch of 2-(tert-Butyldimethylsilyl)Oxyl Alcohol Trifluoromethanesulfonate undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC/NMR), assay, and specific tests is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.