Description

Sulfosuccinimidyl Stearate Sodium is a specialized, long-chain fatty acid-derived N-hydroxysulfosuccinimide (NHS) ester, widely recognized for its utility as a heterobifunctional crosslinking reagent. This compound is engineered to facilitate the stable conjugation of amine-containing molecules to hydrophobic surfaces or other molecules, offering superior aqueous solubility compared to traditional NHS esters. It is essential for researchers and manufacturers in the bioconjugation and materials science fields who require efficient and reliable protein labeling, surface modification, and nanoparticle functionalization. The product is supplied as a high-purity, moisture-sensitive solid to ensure optimal reactivity.

Application

• Protein & Antibody Labeling: Conjugation of fluorescent dyes, enzymes, or other probes to proteins via primary amine groups for diagnostics and imaging.
• Surface Functionalization: Modification of polymeric nanoparticles, liposomes, and microspheres to introduce amine-reactive sites for subsequent biomolecule attachment.
• Biomaterial Engineering: Crosslinking agent in the development of hydrogels, scaffolds, and other matrices for tissue engineering and drug delivery systems.
• Immunoassay Development: Preparation of enzyme-antibody or hapten-carrier protein conjugates used in ELISA and other immunoassay formats.
• PEGylation Chemistry: Intermediate for the synthesis of amine-reactive PEG derivatives used to modify therapeutic proteins and peptides.
• Sensor Fabrication: Immobilization of biorecognition elements (e.g., antibodies, enzymes) onto sensor surfaces for biosensor applications.

Basic Information

Product Name	Sulfosuccinimidyl Stearate Sodium
CAS No.	163451-87-4
Molecular Formula	C22H38NNaO6S
Molecular Weight	467.59 g/mol
Synonyms	Sodium Sulfosuccinimidyl Stearate; N-Hydroxysulfosuccinimide Stearate Ester Sodium Salt; Sulfo-NHS Stearate; Stearic Acid Sulfo-NHS Ester Sodium Salt; 18-Sulfo-NHS Stearate; N-(Stearoyloxy)sulfosuccinimide Sodium Salt; 1-[(Stearoyloxy)sulfonyl]pyrrolidine-2,5-dione Sodium Salt
EINECS	Contact for details

Quality Control

Our Sulfosuccinimidyl Stearate Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, moisture content, and solubility. We adhere to cGMP guidelines where applicable to support our customers in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMF, DMSO
Functional Activity	Conforms (by amine coupling test)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.