Description

Bicyclo[4.2.0]Octa-1,3,5-Triene-7-Carboxylic Acid, (+)- (9Ci) is a high-purity, chiral bicyclic carboxylic acid derivative, distinguished by its unique strained ring structure and specific optical rotation. This compound serves as a sophisticated and versatile chiral building block, enabling the synthesis of complex molecules with precise stereochemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for applications requiring high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or a rigid scaffold in asymmetric catalytic reactions and total synthesis of natural products.
• Ligand and Catalyst Development: Used to construct novel chiral ligands for transition metal catalysis or organocatalysts due to its defined three-dimensional geometry.
• Advanced Material Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms or protein-ligand interactions.
• Process Chemistry: Investigated for scalable routes in the production of enantiomerically pure fine chemicals.

Basic Information

Product Name	Bicyclo[4.2.0]Octa-1,3,5-Triene-7-Carboxylic Acid, (+)- (9Ci)
CAS No.	163222-89-7
Molecular Formula	C9H8O2
Molecular Weight	148.16 g/mol
Synonyms	(+)-Bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid; (7R)-Bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid; (R)-Bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid; Dehydro-7-carboxy-1,2-dihydrobenzocyclobutene; 7-Carboxy-1,2-dihydro-4,5-benzocyclobutene; 1,2-Dihydro-4,5-benzocyclobutene-7-carboxylic acid; (R)-1,2-Dihydro-4,5-benzocyclobutene-7-carboxylic acid
EINECS	Contact for details

Quality Control

Our Bicyclo[4.2.0]Octa-1,3,5-Triene-7-Carboxylic Acid, (+)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific rotation are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Specific Rotation [α]	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.