Description

Cyclopropanecarboxylic Acid, 1-Amino-2-Chloro-, (1S-Trans)- (9Ci) is a high-purity, chiral cyclopropane derivative of significant interest in advanced organic synthesis. This compound serves as a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate the unique conformational and metabolic stability of the cyclopropane ring into new molecular entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex, three-dimensional molecular architectures.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides where the cyclopropane moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Fine Chemical Synthesis: A versatile intermediate for constructing complex natural products and specialty chemicals with high stereochemical fidelity.

Basic Information

Item	Detail
Product Name	Cyclopropanecarboxylic Acid, 1-Amino-2-Chloro-, (1S-Trans)- (9Ci)
CAS No.	163180-53-8
Molecular Formula	C4H6ClNO2
Molecular Weight	135.55 g/mol
Synonyms	(1S,2S)-1-Amino-2-chlorocyclopropanecarboxylic acid; (1S-trans)-1-Amino-2-chlorocyclopropanecarboxylic acid; 1-Amino-2-chlorocyclopropanecarboxylic acid, (1S,2S)-; trans-(1S,2S)-1-Amino-2-chlorocyclopropanecarboxylic acid; 2-Chloro-1-aminocyclopropanecarboxylic acid (1S,2S)-isomer; Cyclopropanecarboxylic acid, 1-amino-2-chloro-, (1S,2S)-; (1S,2S)-2-Chloro-1-aminocyclopropane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarboxylic Acid, 1-Amino-2-Chloro-, (1S-Trans)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination, NMR for structural confirmation, and impurity profiling. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.