Description

(-)-[3R,4S]-Chromanol 293B is a high-purity, stereochemically defined chromanol derivative, a key chiral intermediate and reference standard in advanced pharmaceutical research and development. Its precise stereochemistry is critical for studying and modulating specific biological pathways, particularly in cardiovascular and neurological research. This compound is essential for medicinal chemists, pharmacologists, and analytical scientists working in drug discovery, process development, and quality control for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel therapeutic agents targeting ion channels.
• Biochemical Research: Used as a selective inhibitor (IKs blocker) in cardiac electrophysiology studies to investigate potassium channel function.
• Reference Standard: Serves as a high-purity analytical standard for method development, validation, and quality control in API manufacturing.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Academic Research: Utilized in university and institutional labs for fundamental studies in pharmacology and molecular biology.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for complex chiral molecules.

Basic Information

Product Name	(-)-[3R,4S]-Chromanol 293B
CAS No.	163163-24-4
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Chromanol 293B; (3R,4S)-Chromanol 293B; L-293B; (-)-Chromanol 293B; (3R-cis)-3,4-Dihydro-2,2-dimethyl-4-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methylene]-2H-1-benzopyran-6-ol; IKs blocker 293B; HMR 1556 (related analog)
EINECS	Contact for details

Quality Control

Our (-)-[3R,4S]-Chromanol 293B is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and the absence of critical impurities. A detailed Certificate of Analysis (COA) providing batch-specific results for purity, enantiomeric excess, and related substances is supplied with every order to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.